Social brain activation during mentalizing in a large autism cohort: the Longitudinal European Autism Project.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is a neurodevelopmental condition with key deficits in social functioning. It is widely assumed that the biological underpinnings of social impairment are neurofunctional alterations in the "social brain," a neural circuitry involved in inferring the mental state of a social partner. However, previous evidence comes from small-scale studies and findings have been mixed. We therefore carried out the to-date largest study on neural correlates of mentalizing in ASD.

Methods

As part of the Longitudinal European Autism Project, we performed functional magnetic resonance imaging at six European sites in a large, well-powered, and deeply phenotyped sample of individuals with ASD (N = 205) and typically developing (TD) individuals (N = 189)

SUBMITTER: Moessnang C 

PROVIDER: S-EPMC7036196 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature