MicroRNA expression profiling of peripheral blood mononuclear cells associated with syphilis.

ABSTRACT: BACKGROUND:Treponema pallidum (T. pallidum) infection evokes significant immune responses, resulting in tissue damage. The immune mechanism underlying T. pallidum infection is still unclear, although microRNAs (miRNAs) have been shown to influence immune cell function and, consequently, the generation of antibody responses during other microbe infections. However, these mechanisms are unknown for T. pallidum. METHODS:In this study, we performed a comprehensive analysis of differentially expressed miRNAs in healthy individuals, untreated patients with syphilis, patients in the serofast state, and serologically cured patients. miRNAs were profiled from the peripheral blood of patients obtained at the time of serological diagnosis. Then, both the target sequence analysis of these different mi

SUBMITTER: Huang T 

PROVIDER: S-EPMC7036247 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature