Cytoprotective role of vitamin E in porcine adipose-tissue-derived mesenchymal stem cells against hydrogen-peroxide-induced oxidative stress.

ABSTRACT: Survival of mesenchymal stem cells (MSCs) against oxidative stress and inflammation is vital for effective stem cell therapy. The reactive oxygen species (ROS) result in apoptosis and release of inflammatory mediators. Adipose-derived stem cells (ASCs) have shown promise for stem cell therapy owing to their anti-inflammatory and anti-oxidant activity. Previously, we showed the benefits of vitamin E against hydrogen peroxide (H₂O₂)-induced oxidative stress in rat bone marrow-derived MSCs. In this study, we aim to evaluate the effect of vitamin E treatment on porcine adipose-derived mesenchymal stem cells (pASCs) against H₂O₂-induced oxidative stress. The oxidative stress was induced by treating pASCs with 500 μM H₂O₂ with or

SUBMITTER: Bhatti FUR 

PROVIDER: S-EPMC7036264 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature