The Contribution of the Ankyrin Repeat Domain of TRPV1 as a Thermal Module.

ABSTRACT: The TRPV1 cation nonselective ion channel plays an essential role in thermosensation and perception of other noxious stimuli. TRPV1 can be activated by low extracellular pH, high temperature, or naturally occurring pungent molecules such as allicin, capsaicin, or resiniferatoxin. Its noxious thermal sensitivity makes it an important participant as a thermal sensor in mammals. However, details of the mechanism of channel activation by increases in temperature remain unclear. Here, we used a combination of approaches to try to understand the role of the ankyrin repeat domain (ARD) in channel behavior. First, a computational modeling approach by coarse-grained molecular dynamics simulation of the whole TRPV1 embedded in a phosphatidylcholine and phosphatidylethanolamine membrane provides insi

SUBMITTER: Ladron-de-Guevara E 

PROVIDER: S-EPMC7036727 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature