Role of Actin Cytoskeleton in Dynamics and Function of the Serotonin_1A Receptor.

ABSTRACT: G protein-coupled receptors (GPCRs) are important membrane proteins in higher eukaryotes that carry out a vast array of cellular signaling and act as major drug targets. The serotonin_1A receptor is a prototypical member of the GPCR family and is implicated in neuropsychiatric disorders such as anxiety and depression, besides serving as an important drug target. With an overall goal of exploring the functional consequence of altered receptor dynamics, in this work, we probed the role of the actin cytoskeleton in the dynamics, ligand binding, and signaling of the serotonin_1A receptor. We monitored receptor dynamics utilizing single particle tracking, which provides information on relative distribution of receptors in various diffusion modes in addition to diffusion coef

SUBMITTER: Shrivastava S 

PROVIDER: S-EPMC7036728 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature