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Neo-Aplysiatoxin A Isolated from Okinawan Cyanobacterium Moorea Producens.

ABSTRACT: A new aplysiatoxin derivative, neo-aplysiatoxin A (1), along with seven known compounds, neo-debromoaplysiatoxin A (2), dolastatin 3 (3), lyngbic acid (4), malyngamide M (5), hermitamide A (6), (-)-loliolide (7), and (+)-epiloliolide (8), was isolated from the Okinawan cyanobacterium Moorea producens. Their structures were elucidated on the basis of spectroscopic data, including high-resolution mass spectrometry and nuclear magnetic resonance. The compounds were evaluated for cytotoxic and diatom growth inhibition activities.

SUBMITTER: Kawaguchi M 

PROVIDER: S-EPMC7037229 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Neo-Aplysiatoxin A Isolated from Okinawan Cyanobacterium <i>Moorea Producens</i>.

Kawaguchi Mioko M   Satake Masayuki M   Zhang Bo-Tao BT   Xiao Yue-Yun YY   Fukuoka Masayuki M   Uchida Hajime H   Nagai Hiroshi H  

Molecules (Basel, Switzerland) 20200122 3

A new aplysiatoxin derivative, neo-aplysiatoxin A (<b>1</b>), along with seven known compounds, neo-debromoaplysiatoxin A (<b>2</b>), dolastatin 3 (<b>3</b>), lyngbic acid (<b>4</b>), malyngamide M (<b>5</b>), hermitamide A (<b>6</b>), (-)-loliolide (<b>7</b>), and (+)-epiloliolide (<b>8</b>), was isolated from the Okinawan cyanobacterium <i>Moorea producens</i>. Their structures were elucidated on the basis of spectroscopic data, including high-resolution mass spectrometry and nuclear magnetic  ...[more]

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