Inflammatory Biomarkers, Microbiome, Depression, and Executive Dysfunction in Alcohol Users.

ABSTRACT: Alcohol-related disorders (ARD) are highly prevalent among Latin American-Caribbean countries. Mental disorders are common comorbidities in individuals with ARD. However, the etiology of the association between ARD and mental disorders remains unclear. We examined the association of inflammatory cytokines, microbiome, and other biomakers with measures of depression, social anxiety, and executive functions. We observed a significant increase in cytokine and chemokine expression levels in saliva and plasma in the alcohol group (AG) samples. Also, the salivary bacterial composition in the AG revealed an abundance of Prevotella. Depression symptomatology was markedly higher in the AG, but social anxiety levels were negligible. AG also exhibited executive dysfunctions, which negatively c

SUBMITTER: Rodriguez-Rabassa M 

PROVIDER: S-EPMC7037324 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature