Estradiol-17β-Induced Changes in the Porcine Endometrial Transcriptome In Vivo.

ABSTRACT: Estradiol-17β (E2) is a key hormone regulating reproductive functions in females. In pigs, E2, as the main conceptus signal, initiates processes resulting in prolonged corpus luteum function, embryo development, and implantation. During early pregnancy the endometrium undergoes morphological and physiological transitions that are tightly related to transcriptome changes. Recently, however, the importance of E2 as a primary conceptus signal in the pig has been questionable. Thus, the aim of the present study was to determine the effects of E2 on the porcine endometrial transcriptome in vivo and to compare these effects with transcriptome profiles on day 12 of pregnancy. Microarray analysis revealed differentially expressed genes (DEGs) in response to E2 with overrepresented functional terms

SUBMITTER: Kaczynski P 

PROVIDER: S-EPMC7037416 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature