Synthesis of Functionalized Cannabilactones.

ABSTRACT: A new approach to synthesize cannabilactones using Suzuki cross-coupling reaction followed by one-step demethylation-cyclization is presented. The two key cannabilactone prototypes AM1710 and AM1714 were obtained selectively in high overall yields and in a lesser number of synthetic steps when compared to our earlier synthesis. The new approach expedited the synthesis of cannabilactone analogs with structural modifications at the four potential pharmacophoric regions.

SUBMITTER: Liu Y 

PROVIDER: S-EPMC7037859 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature