Poly(ADP-Ribose) Polymerase-3 Regulates Regeneration in Planarians.

ABSTRACT: Protein ADP-ribosylation is a reversible post-translational modification (PTM) process that plays fundamental roles in cell signaling. The covalent attachment of ADP ribose polymers is executed by PAR polymerases (PARP) and it is essential for chromatin organization, DNA repair, cell cycle, transcription, and replication, among other critical cellular events. The process of PARylation or polyADP-ribosylation is dynamic and takes place across many tissues undergoing renewal and repair, but the molecular mechanisms regulating this PTM remain mostly unknown. Here, we introduce the use of the planarian Schmidtea mediterranea as a tractable model to study PARylation in the complexity of the adult body that is under constant renewal and is capable of regenerating damaged tissues. We identified t

SUBMITTER: Barghouth PG 

PROVIDER: S-EPMC7038108 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature