Study on the Synthesis, Antioxidant Properties, and Self-Assembly of Carotenoid-Flavonoid Conjugates.

ABSTRACT: Flavonoids and carotenoids possess beneficial physiological effects, such as high antioxidant capacity, anticarcinogenic, immunomodulatory, and anti-inflammatory properties, as well as protective effects against UV light. The covalent coupling of hydrophobic carotenoids with hydrophilic flavonoids, such as daidzein and chrysin, was achieved, resulting in new amphipathic structures. 7-Azidohexyl ethers of daidzein and chrysin were prepared in five steps, and their azide-alkyne [4 + 2] cycloaddition with pentynoates of 8'-apo-β-carotenol, zeaxanthin, and capsanthin afforded carotenoid-flavonoid conjugates. The trolox-equivalent antioxidant capacity against ABTS^•+ radical cation and self-assembly of the final products were examined. The 1:1 flavonoid-carotenoid hybrids generally sh

SUBMITTER: Linzembold I 

PROVIDER: S-EPMC7038153 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature