Impact of Candida auris Infection in a Neutropenic Murine Model.

ABSTRACT: Candida auris has become a global public health threat due to its multidrug resistance and persistence. Currently, there are limited murine models to study C. auris infection. Those models use a combination of cyclophosphamide and cortisone acetate, suppressing both innate and adaptive immunity. Here, we compare C. auris infection in two neutrophil-depleted murine models in which innate immunity is targeted using the monoclonal antibodies 1A8 and RB6-8C5.

SUBMITTER: Torres SR 

PROVIDER: S-EPMC7038241 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature