Population Pharmacokinetics and Dosing of Ethionamide in Children with Tuberculosis.

ABSTRACT: Ethionamide has proven efficacy against both drug-susceptible and some drug-resistant strains of Mycobacterium tuberculosis Limited information on its pharmacokinetics in children is available, and current doses are extrapolated from weight-based adult doses. Pediatric doses based on more robust evidence are expected to improve antituberculosis treatment, especially in small children. In this analysis, ethionamide concentrations in children from 2 observational clinical studies conducted in Cape Town, South Africa, were pooled. All children received ethionamide once daily at a weight-based dose of approximately 20 mg/kg of body weight (range, 10.4 to 25.3 mg/kg) in combination with other first- or second-line antituberculosis medications and with antiretroviral therapy in cases of H

SUBMITTER: Bjugard Nyberg H 

PROVIDER: S-EPMC7038277 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature