Identification of DNA N⁶-methyladenine sites by integration of sequence features.

ABSTRACT:

Background

An increasing number of nucleic acid modifications have been profiled with the development of sequencing technologies. DNA N⁶-methyladenine (6mA), which is a prevalent epigenetic modification, plays important roles in a series of biological processes. So far, identification of DNA 6mA relies primarily on time-consuming and expensive experimental approaches. However, in silico methods can be implemented to conduct preliminary screening to save experimental resources and time, especially given the rapid accumulation of sequencing data.

Results

In this study, we constructed a 6mA predictor, p6mA, from a series of sequence-based features, including physicochemical properties, position-specific triple-nucleotide propensity (PSTNP), and electron-ion interacti

SUBMITTER: Wang HT 

PROVIDER: S-EPMC7038560 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature