Downregulation of type I collagen expression in the Achilles tendon by dexamethasone: a controlled laboratory study.

ABSTRACT:

Background

Spontaneous Achilles tendon rupture associated with long-term dexamethasone (Dex) use has been reported. However, few studies have investigated the potential mechanism. The aim of this study was to evaluate the effects of oral Dex on type I collagen in humans and rats and its association with tendon rupture.

Methods

First, six Achilles tendons from patients who received long-term Dex treatment, and another six normal tendons were harvested for histological evaluation. Secondly, 8-week-old rats (n = 72) were randomly assigned to a Dex group or a control group. Type I collagen was studied at the mechanical, histological, and molecular levels after 3 and 5 weeks. Tenocytes isolated from normal human and rat tendon were used to investigate the effect of Dex on cellula

SUBMITTER: Ge Z 

PROVIDER: S-EPMC7038574 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature