CD4⁺CD38⁺ central memory T cells contribute to HIV persistence in HIV-infected individuals on long-term ART.

ABSTRACT:

Background

Despite the effective antiretroviral treatment (ART) of HIV-infected individuals, HIV persists in a small pool. Central memory CD4⁺ T cells (Tcm) make a major contribution to HIV persistence. We found that unlike HLA-DR, CD38 is highly expressed on the Tcm of HIV-infected subjects receiving ART for > 5 years. It has been reported that the half-life of total and episomal HIV DNA in the CD4⁺CD38⁺ T cell subset, exhibits lower decay rates at 12 weeks of ART. Whether CD38 contributes to HIV latency in HIV-infected individuals receiving long-term ART is yet to be addressed.

Methods

Peripheral blood mononuclear cells (PBMCs) were isolated from the whole blood of HIV-infected subjects receiving suppressive ART. The immunophenotyping, prol

SUBMITTER: Song CB 

PROVIDER: S-EPMC7038621 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature