Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept.

ABSTRACT:

Background

In light of the vulnerability of the developing brain, mixture risk assessment (MRA) for the evaluation of developmental neurotoxicity (DNT) should be implemented, since infants and children are co-exposed to more than one chemical at a time. One possible approach to tackle MRA could be to cluster DNT chemicals in a mixture on the basis of their mode of action (MoA) into 'similar' and 'dissimilar', but still contributing to the same adverse outcome, and anchor DNT assays to common key events (CKEs) identified in DNT-specific adverse outcome pathways (AOPs). Moreover, the use of human in vitro models, such as induced pluripotent stem cell (hiPSC)-derived neuronal and glial cultures would enable mechanistic understanding of chemically-induced adverse effects, avoiding spec

SUBMITTER: Pistollato F 

PROVIDER: S-EPMC7038628 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature