Mouse PVRIG Has CD8⁺ T Cell-Specific Coinhibitory Functions and Dampens Antitumor Immunity.

ABSTRACT: A limitation to antitumor immunity is the dysfunction of T cells in the tumor microenvironment, in part due to upregulation of coinhibitory receptors such as PD-1. Here, we describe that poliovirus receptor-related immunoglobulin domain protein (PVRIG) acts as a coinhibitory receptor in mice. Murine PVRIG interacted weakly with poliovirus receptor (PVR) but bound poliovirus receptor-like 2 (PVRL2) strongly, making the latter its principal ligand. As in humans, murine NK and NKT cells constitutively expressed PVRIG. However, when compared with humans, less PVRIG transcript and surface protein was detected in murine CD8⁺ T cells ex vivo However, activated CD8⁺ T cells upregulated PVRIG expression. In the mouse tumor microenvironment, infiltrating CD8⁺

SUBMITTER: Murter B 

PROVIDER: S-EPMC7038785 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature