Neurogranin Regulates Alcohol Sensitivity through AKT Pathway in the Nucleus Accumbens.

ABSTRACT: Dysfunction of glutamate neurotransmission in the nucleus accumbens (NAc) has been implicated in the pathophysiology of alcohol use disorders (AUD). Neurogranin (Ng) is exclusively expressed in the brain and mediates N-methyl-d-aspartate receptor (NMDAR) hypo-function by regulating the intracellular calcium-calmodulin (Ca²⁺ -CaM) pathway. Ng null mice (Ng^-/- mice) demonstrate increased alcohol drinking compared to wild-type mice, while also showing less tolerance to the effect of alcohol. To identify the molecular mechanism related to alcohol seeking, both in vivo microdialysis and label-free quantification proteomics comparing Ng genotype and effects of alcohol treatment on the NAc are utilized. There is significant difference in glutamate and gamma-aminobutyric acid

SUBMITTER: Nam HW 

PROVIDER: S-EPMC7038789 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature