Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC7039046 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Zhang Yao Y Shi Xuechen X Zhao Tiankai T Huang Changjin C Wei Qiong Q Tang Xin X Santy Lorraine C LC Saif M Taher A MTA Zhang Sulin S
Soft matter 20190901 36
Cancer metastasis has been believed as a genetically programmed process that is commonly marked by biochemical signals. Here using extracellular matrix control of cellular mechanics, we establish that cellular force threshold can also mark in vitro metastatic phenotypic change and malignant transformation in HCT-8 cell colonies. We observe that for prolonged culture time the HCT-8 cell colonies disperse into individual malignant cells, and the metastatic-like dispersion depends on both cell-seed ...[more]