IRF1 association with tumor immune microenvironment and use as a diagnostic biomarker for colorectal cancer recurrence.

ABSTRACT: Colorectal cancer (CRC) is considered to be one of the most lethal cancer types globally, and its recurrence is a major treatment challenge. Identifying the factors involved when determining the risk of CRC recurrence is required to improve personalized therapy for patients with CRC. Based on the GSE39582 dataset, the present study demonstrated that a higher ratio of M1 macrophages and activated memory CD4⁺ T cells indicated a better recurrence-free survival (RFS) time for CRC, using CIBERSORT and Pearson's correlation analysis. Through weighted correlation network analysis (WGCNA), an immune-associated module was identified that was significantly positively correlated with the ratio of M1 macrophages and activated memory CD4⁺ T cells. In this module, using WGCNA and

SUBMITTER: Wu Y 

PROVIDER: S-EPMC7039159 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature