Ca2+ transients in melanocyte dendrites and dendritic spine-like structures evoked by cell-to-cell signaling.

ABSTRACT: Melanocytes are the neural crest-derived pigment-producing cells of the skin that possess dendrites. Yet little is known about how melanocyte dendrites receive and process information from neighboring cells. Here, using a co-culture system to interrogate the interaction between melanocyte dendrites and keratinocytes, we show that signals from neighboring keratinocytes trigger local compartmentalized Ca2+ transients within the melanocyte dendrites. The localized dendritic Ca2+ transients could be triggered by two keratinocyte-secreted factors, endothelin and acetylcholine, which acted via specific melanocyte receptors. Furthermore, compartmentalized Ca2+ transients were also generated on discrete dendritic spine-like structures on the melanocytes. These spines were also present in intact hu

SUBMITTER: Belote RL 

PROVIDER: S-EPMC7039208 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature