Distinct Polysaccharide Utilization Profiles of Human Intestinal Prevotella copri Isolates.

ABSTRACT: Gut-dwelling Prevotella copri (P. copri), the most prevalent Prevotella species in the human gut, have been associated with diet and disease. However, our understanding of their diversity and function remains rudimentary because studies have been limited to 16S and metagenomic surveys and experiments using a single type strain. Here, we describe the genomic diversity of 83 P. copri isolates from 11 human donors. We demonstrate that genomically distinct isolates, which can be categorized into different P. copri complex clades, utilize defined sets of polysaccharides. These differences are exemplified by variations in susC genes involved in polysaccharide transport as well as polysaccharide utilization loci (PULs) that were predicted in part from genomic and metagenomic data. Functional vali

SUBMITTER: Fehlner-Peach H 

PROVIDER: S-EPMC7039456 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature