DAPLE protein inhibits nucleotide exchange on Gα_s and Gα_q via the same motif that activates Gαi.

ABSTRACT: Besides being regulated by G-protein-coupled receptors, the activity of heterotrimeric G proteins is modulated by many cytoplasmic proteins. GIV/Girdin and DAPLE (Dvl-associating protein with a high frequency of leucine) are the best-characterized members of a group of cytoplasmic regulators that contain a Gα-binding and -activating (GBA) motif and whose dysregulation underlies human diseases, including cancer and birth defects. GBA motif-containing proteins were originally reported to modulate G proteins by binding Gα subunits of the G_i/o family (Gα_i) over other families (such as G_s, G_q/11, or G_12/13), and promoting nucleotide exchange in vitro However, some evidence suggests that this is not always

SUBMITTER: Marivin A 

PROVIDER: S-EPMC7039542 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature