Lack of association of genetic variants for diabetic retinopathy in Taiwanese patients with diabetic nephropathy.

ABSTRACT:

Objective

Diabetic nephropathy (DN) and diabetic retinopathy (DR) comprise major microvascular complications of diabetes that occur with a high concordance rate in patients and are considered to potentially share pathogeneses. In this case-control study, we sought to investigate whether DR-related single nucleotide polymorphisms (SNPs) exert pleiotropic effects on renal function outcomes among patients with diabetes.

Research design and methods

A total of 33 DR-related SNPs were identified by replicating published SNPs and via a genome-wide association study. Furthermore, we assessed the cumulative effects by creating a weighted genetic risk score and evaluated the discriminatory and prediction ability of these genetic variants using DN cases according to estimated glomerula

SUBMITTER: Hsieh AR 

PROVIDER: S-EPMC7039583 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature