Genetic factors and risk of type 2 diabetes among women with a history of gestational diabetes: findings from two independent populations.

ABSTRACT:

Objective

Women with a history of gestational diabetes mellitus (GDM) have an exceptionally high risk for type 2 diabetes (T2D). Yet, little is known about genetic determinants for T2D in this population. We examined the association of a genetic risk score (GRS) with risk of T2D in two independent populations of women with a history of GDM and how this association might be modified by non-genetic determinants for T2D.

Research design and methods

This cohort study included 2434 white women with a history of GDM from the Nurses' Health Study II (NHSII, n=1884) and the Danish National Birth Cohort (DNBC, n=550). A GRS for T2D was calculated using 59 candidate single nucleotide polymorphisms for T2D identified from genome-wide association studies in European populations. An alte

SUBMITTER: Li M 

PROVIDER: S-EPMC7039588 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature