Pharmacogenetics predictors of methylphenidate efficacy in childhood ADHD.

ABSTRACT: Stimulant medication has long been effective in treating attention-deficit/hyperactivity disorder (ADHD) and is currently the first-line pharmacological treatment for children. Both methylphenidate and amphetamine modulate extracellular catecholamine levels through interaction with dopaminergic, adrenergic and serotonergic system components; it is therefore likely that catecholaminergic molecular components influence the effects of ADHD treatment. Using meta-analysis, we sought to identify predictors of pharmacotherapy to further the clinical implementation of personalized medicine. We identified 36 studies (3647 children) linking the effectiveness of methylphenidate treatment with DNA variants. Pooled-data revealed a statistically significant association between single nucleotide polymorp

SUBMITTER: Myer NM 

PROVIDER: S-EPMC7039663 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature