Aberrant Brain Functional Connectivity Dynamic Responses to the Valsalva Maneuver in Heart Failure.

ABSTRACT: BACKGROUND:Patients with heart failure (HF) show abnormal autonomic activities, which may stem from altered functional connectivity (FC) between different brain sites. METHODS AND RESULTS:We evaluate insular and cerebellar FC with other brain areas, before, during, and after the Valsalva challenge, with functional magnetic resonance imaging in 35 HF and 35 control subjects. Significant insular FC emerged with striatum, thalamus, and anterior cingulate. While left and right cerebellar cortices showed significant FC with each other constituting the cerebellum network, the insula and cerebellum networks showed significant negative FC with each other at baseline, challenge, and recovery phases. The challenge induced increased FC within the insula and the cerebellum networks in both HF and cont

SUBMITTER: Song X 

PROVIDER: S-EPMC7039687 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature