Ontology highlight
ABSTRACT:
SUBMITTER: Fredens J
PROVIDER: S-EPMC7039709 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Fredens Julius J Wang Kaihang K de la Torre Daniel D Funke Louise F H LFH Robertson Wesley E WE Christova Yonka Y Chia Tiongsun T Schmied Wolfgang H WH Dunkelmann Daniel L DL Beránek Václav V Uttamapinant Chayasith C Llamazares Andres Gonzalez AG Elliott Thomas S TS Chin Jason W JW
Nature 20190515 7757
Nature uses 64 codons to encode the synthesis of proteins from the genome, and chooses 1 sense codon-out of up to 6 synonyms-to encode each amino acid. Synonymous codon choice has diverse and important roles, and many synonymous substitutions are detrimental. Here we demonstrate that the number of codons used to encode the canonical amino acids can be reduced, through the genome-wide substitution of target codons by defined synonyms. We create a variant of Escherichia coli with a four-megabase s ...[more]