Ontology highlight
ABSTRACT:
SUBMITTER: Fredens J
PROVIDER: S-EPMC7039709 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Nature 20190515 7757
Nature uses 64 codons to encode the synthesis of proteins from the genome, and chooses 1 sense codon-out of up to 6 synonyms-to encode each amino acid. Synonymous codon choice has diverse and important roles, and many synonymous substitutions are detrimental. Here we demonstrate that the number of codons used to encode the canonical amino acids can be reduced, through the genome-wide substitution of target codons by defined synonyms. We create a variant of Escherichia coli with a four-megabase s ...[more]