Mitral regurgitation worsens cardiac remodeling in ischemic cardiomyopathy in an experimental model.

ABSTRACT:

Objective

Mitral regurgitation (MR) developing concomitant with ischemic cardiomyopathy is a frequently diagnosed valvular lesion, for which an optimal therapeutic strategy is unknown. The contribution of MR to the ongoing cardiac remodeling from myocardial infarction (MI) remains controversial. We have developed a novel experimental model in which MI and severe MR can be independently introduced, to study the role of MR in chronic remodeling of the ischemic heart.

Methods

A total of 98 rats were induced with MI+MR (group 1), MI (group 2), MR (group 3), or sham surgery (group 4). MR was induced by inserting a needle into the anterior mitral leaflet via the ventricular apex in a beating heart. MI was induced by ligating the left coronary artery. Biweekly ultrasound examinatio

SUBMITTER: Onohara D 

PROVIDER: S-EPMC7039765 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature