Mother-child histocompatibility and risk of rheumatoid arthritis and systemic lupus erythematosus among mothers.

ABSTRACT: The study objective was to test the hypothesis that having histocompatible children increases the risk of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), possibly by contributing to the persistence of fetal cells acquired during pregnancy. We conducted a case control study using data from the UC San Francisco Mother Child Immunogenetic Study and studies at the Inova Translational Medicine Institute. We imputed human leukocyte antigen (HLA) alleles and minor histocompatibility antigens (mHags). We created a variable of exposure to histocompatible children. We estimated an average sequence similarity matching (SSM) score for each mother based on discordant mother-child alleles as a measure of histocompatibility. We used logistic regression models to estimate odds ratios (OR

SUBMITTER: Cruz GI 

PROVIDER: S-EPMC7039805 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature