Neural cell integration into 3D bioprinted skeletal muscle constructs accelerates restoration of muscle function.

ABSTRACT: A bioengineered skeletal muscle construct that mimics structural and functional characteristics of native skeletal muscle is a promising therapeutic option to treat extensive muscle defect injuries. We previously showed that bioprinted human skeletal muscle constructs were able to form multi-layered bundles with aligned myofibers. In this study, we investigate the effects of neural cell integration into the bioprinted skeletal muscle construct to accelerate functional muscle regeneration in vivo. Neural input into this bioprinted skeletal muscle construct shows the improvement of myofiber formation, long-term survival, and neuromuscular junction formation in vitro. More importantly, the bioprinted constructs with neural cell integration facilitate rapid innervation and mature into organize

SUBMITTER: Kim JH 

PROVIDER: S-EPMC7039897 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature