High-contrast, fast chemical imaging by coherent Raman scattering using a self-synchronized two-colour fibre laser.

ABSTRACT: Coherent Raman scattering (CRS) microscopy is widely recognized as a powerful tool for tackling biomedical problems based on its chemically specific label-free contrast, high spatial and spectral resolution, and high sensitivity. However, the clinical translation of CRS imaging technologies has long been hindered by traditional solid-state lasers with environmentally sensitive operations and large footprints. Ultrafast fibre lasers can potentially overcome these shortcomings but have not yet been fully exploited for CRS imaging, as previous implementations have suffered from high intensity noise, a narrow tuning range and low power, resulting in low image qualities and slow imaging speeds. Here, we present a novel high-power self-synchronized two-colour pulsed fibre laser that achieves exc

SUBMITTER: Kong C 

PROVIDER: S-EPMC7039946 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature