Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates.

ABSTRACT: Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipolar disorder (BP) in numerous multigenerational pedigrees suggests that, in such families, large-effect inherited variants might play a greater role. To identify roles of rare and common variants on BP, we conducted genetic analyses in 26 Colombia and Costa Rica pedigrees ascertained for bipolar disorder 1 (BP1), the most severe and heritable form of BP. In these pedigrees, we performed microarray SNP genotyping of 838 individuals and high-coverage whole-genome sequencing of 449 individuals. We compared polygenic risk scores (PRS), estimated using the lates

SUBMITTER: Sul JH 

PROVIDER: S-EPMC7039961 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature