Interactions between a Polygenic Risk Score and Non-genetic Risk Factors in Young-Onset Breast Cancer.

ABSTRACT: Most gene-environmental studies have focused on breast cancers generally, the preponderance of which occur after age 50. Young-onset breast cancers (YOBC) tend to be aggressive and may be etiologically different. The goal of this analysis was to assess interactions between an established 77-SNP polygenic risk score (PRS) and non-genetic risk factors for YOBC. We constructed the PRS using a family-based study of 1,291 women diagnosed with breast cancer before age 50 and their parents and unaffected sisters. We used conditional logistic regression to analyze interactions between the PRS and 14 established risk factors. In further analyses we assessed the same interactions, but for invasive cancer, estrogen receptor (ER) positive cancer and with broader inclusion of racial/ethnic groups. Resu

SUBMITTER: Shi M 

PROVIDER: S-EPMC7039983 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature