Optimization of PET protocol and interrater reliability of ¹⁸F-PSMA-11 imaging of prostate cancer.

ABSTRACT:

Background

Several scan parameters for PET imaging with ¹⁸F-PSMA-11 such as dosage, acquisition time and scan duration were evaluated to determine the most appropriate scan protocol, as well as the effect of furosemide administration on lesion visualization. Forty-four patients were randomly assigned to a dosage group (2.0 ± 0.2 or 4.0 ± 0.4 MBq/kg ¹⁸F-PSMA-11). All patients received a full-body PET/CT 1 h and 3 h after radiotracer injection with a scan duration of 3 min/bed position. For comparison of the scan duration, images were reconstructed for 1.5 and 3 min/bed position. Patients were intravenously administered 0.5 mg/kg furosemide with a maximum dose of 40 mg. To evaluate the furosemide effect, 22 additional patients were recruited and received one ful

SUBMITTER: Piron S 

PROVIDER: S-EPMC7040121 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature