Global coagulation assays in hemophilia A: A comparison to conventional assays.

ABSTRACT:

Background

Global assays measure the interactions of coagulants, anticoagulants, and platelets on thrombin generation and may reflect the comprehensive coagulation potential in patients with hemophilia better than conventional assays.

Objectives

The objectives of the current study were to investigate the value of global assays for measuring and monitoring the coagulation potential of patients with hemophilia A (HA).

Patients/methods

Rotational thromboelastometry, thrombin generation assay (TGA), and activated partial thromboplastin time (APTT) clot waveform analysis were investigated in a cohort of patients with severe, moderate, and mild HA and compared with conventional assays.

Results

The maximum velocity (MaxVel) parameter of modified thromboelastometry ana

SUBMITTER: Aghighi S 

PROVIDER: S-EPMC7040542 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature