Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromso Study.

ABSTRACT:

Background

The risk of venous thromboembolism (VTE) is increased after a myocardial infarction (MI). Some prothrombotic genotypes associated with VTE have also been associated with risk of MI. Whether prothrombotic single-nucleotide polymorphisms (SNPs) further increase the risk of VTE in MI patients is scarcely investigated.

Aim

To study the combined effect of MI and prothrombotic SNPs on the risk of VTE.

Methods

Cases with incident VTE (n = 641) and a randomly sampled subcohort weighted for age (n = 1761) were identified from the 4 to 6 surveys of the Tromsø Study (1994-2012). DNA was genotyped for rs8176719 (ABO), rs6025 (F5), rs1799963 (F2), rs2066865 (FGG), and rs2036914 (F11). Hazard ratios (HRs) for VTE with 95% confidence int

SUBMITTER: Sejrup JK 

PROVIDER: S-EPMC7040547 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature