Central EP3 (E Prostanoid 3) Receptors Mediate Salt-Sensitive Hypertension and Immune Activation.

ABSTRACT: We recently identified a pathway underlying immune activation in hypertension. Proteins oxidatively modified by reactive isoLG (isolevuglandin) accumulate in dendritic cells (DCs). PGE₂ (Prostaglandin E2) has been implicated in the inflammation associated with hypertension. We hypothesized that PGE₂ via its EP (E prostanoid) 3 receptor contributes to DC activation in hypertension. EP3^-/- mice and wild-type littermates were exposed to sequential hypertensive stimuli involving an initial 2-week exposure to the nitric oxide synthase inhibitor N^ω-nitro-L-arginine methyl ester hydrochloride in drinking water, followed by a 2-week washout period, and a subsequent 4% high-salt diet for 3 weeks. In wild-type mice, this protocol increased systolic pressur

SUBMITTER: Xiao L 

PROVIDER: S-EPMC7040566 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature