Serum Copeptin levels in the emergency department predict major clinical outcomes in adult trauma patients.

ABSTRACT:

Background

Early prognostication in trauma patients is challenging, but particularly important. We wanted to explore the ability of copeptin, the C-terminal fragment of arginine vasopressin, to identify major trauma, defined as Injury Severity Score (ISS) > 15, in a heterogeneous cohort of trauma patients and to compare its performances with lactate. We also evaluated copeptin performance in predicting other clinical outcomes: mortality, hospital admission, blood transfusion, emergency surgery, and Intensive Care Unit (ICU) admission.

Methods

This single center, pragmatic, prospective observational study was conducted at Arcispedale Santa Maria Nuova, a level II trauma center in Reggio Emilia, Italy. Copeptin determination was obtained on Emergency Department (ED) arrival, t

SUBMITTER: Salvo F 

PROVIDER: S-EPMC7041089 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature