GSAlign: an efficient sequence alignment tool for intra-species genomes.

ABSTRACT: BACKGROUND:Personal genomics and comparative genomics are becoming more important in clinical practice and genome research. Both fields require sequence alignment to discover sequence conservation and variation. Though many methods have been developed, some are designed for small genome comparison while some are not efficient for large genome comparison. Moreover, most existing genome comparison tools have not been evaluated the correctness of sequence alignments systematically. A wrong sequence alignment would produce false sequence variants. RESULTS:In this study, we present GSAlign that handles large genome sequence alignment efficiently and identifies sequence variants from the alignment result. GSAlign is an efficient sequence alignment tool for intra-species genomes. It identifies se

SUBMITTER: Lin HN 

PROVIDER: S-EPMC7041101 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature