Seasonal effect on fatigue, pain and dryness in primary Sjogren's syndrome.

ABSTRACT: BACKGROUND:To assess the presence of a seasonal effect on fatigue, pain and dryness in primary Sjögren's syndrome (pSS). METHODS:Data (date; visual analogue scales (VAS) for pain, fatigue and dryness) were extracted from three randomised placebo-controlled trials (RCTs) evaluating infliximab (TRIPSS; n = 103 patients), hydroxychloroquine (JOQUER; n = 120 patients) and rituximab (TEARS; n = 120 patients) and from the 5-year follow-up of the ASSESS prospective cohort (n = 395 patients). Data were analysed at each visit for each patient, according to the day, the month of the year and the season. Linear mixed models were used to take into account the repeated structure of the data and to analyse a potential cyclic effect. RESULTS:A total of 744, 584, 848 and 682 pain, fatigue and dryness VASs

SUBMITTER: Duret PM 

PROVIDER: S-EPMC7041128 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature