Unstimulated whole saliva flow for diagnosis of primary Sjogren's syndrome: time to revisit the threshold?

ABSTRACT: BACKGROUND:Unstimulated whole saliva (UWS) flow rate is one of the ACR/EULAR 2016 criteria for primary Sjögren's syndrome (pSS). With a single threshold of ??0.1?mL/min, UWS flow does not take into account the age- and sex-related physiological variations. Furthermore, it has a low sensitivity for the diagnosis of pSS (about 50%), contrary to the screening test for xerophthalmia, Schirmer's test (sensitivity of about 70%). We aimed to identify UWS thresholds allowing better performances for a screening test for pSS comparable to Schirmer's test, and considering age- and sex-related variations. METHODS:A prospective cohort of 185 patients with oral and/or ocular dryness was classified into 3 groups: men, women

SUBMITTER: Lacombe V 

PROVIDER: S-EPMC7041275 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature