Second Generation Nanoporous Silicon Nitride Membranes for High Toxin Clearance and Small Format Hemodialysis.

ABSTRACT: Conventional hemodialysis (HD) uses floor-standing instruments and bulky dialysis cartridges containing ≈2 m² of 10 micrometer thick, tortuous-path membranes. Portable and wearable HD systems can improve outcomes for patients with end-stage renal disease by facilitating more frequent, longer dialysis at home, providing more physiological toxin clearance. Developing devices with these benefits requires highly efficient membranes to clear clinically relevant toxins in small formats. Here, the ability of ultrathin (<100 nm) silicon-nitride-based membranes to reduce the membrane area required to clear toxins by orders of magnitude is shown. Advanced fabrication methods are introduced that produce nanoporous silicon nitride membranes (NPN-O) that are two times stronger than the origi

SUBMITTER: Hill K 

PROVIDER: S-EPMC7041421 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature