Overcoming barriers to reprogramming and differentiation in nonhuman primate induced pluripotent stem cells.

ABSTRACT: Induced pluripotent stem cells (iPS cells) generated by cellular reprogramming from nonhuman primates (NHPs) are of great significance for regenerative medicine and for comparative biology. Autologously derived stem cells would theoretically avoid any risk of rejection due to host-donor mismatch and may bypass the need for immune suppression post-transplant. In order for these possibilities to be realized, reprogramming methodologies that were initially developed mainly for human cells must be translated to NHPs. NHP studies have typically used pluripotent cells generated from young animals and thus risk overlooking complications that may arise from generating iPS cells from donors of other ages. When reprogramming is extended to a wide range of NHP species, available donors may be middle-

SUBMITTER: Hemmi JJ 

PROVIDER: S-EPMC7041531 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature