Baboon induced pluripotent stem cell generation by piggyBac transposition of reprogramming factors.

ABSTRACT: Clinical application of regenerative therapies using embryonic or induced pluripotent stem cells is within reach. Progress made during recent years has encouraged researchers to address remaining open questions in order to finally translate experimental cell replacement therapies into application in patients. To achieve this, studies in translationally relevant animal models are required to make the final step to the clinic. In this context, the baboon (Papio anubis) may represent a valuable nonhuman primate (NHP) model to test cell replacement therapies because of its close evolutionary relationship to humans and its large body size. In this study, we describe the reprogramming of adult baboon skin fibroblasts using the piggyBac transposon system. Via transposon-mediated ove

SUBMITTER: Rodriguez-Polo I 

PROVIDER: S-EPMC7041535 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature