Aucubin exerts anti-osteoporotic effects by promoting osteoblast differentiation.

ABSTRACT: Osteoporosis is a metabolic disease characterized by reduced osteoblast differentiation and proliferation. Oxidative stress plays a role in the pathogenesis of osteoporosis. Aucubin (AU), an iridoid glycoside, was previously shown to promote osteoblast differentiation. We investigated the effects of AU on MG63 human osteoblast-like cells treated with dexamethasone (Dex) or hydrogen peroxide (H₂O₂) to induce oxidative damage. AU protected MG63 cells against apoptosis, and promoted increased expression of cytokines associated with osteoblast differentiation, including collagen I, osteocalcin (OCN), osteopontin (OPN), and osterix. In Dex- and H₂O₂-treated MG63 cells, AU also enhanced the expression of anti-oxidative stress-associated factors in the

SUBMITTER: Li Y 

PROVIDER: S-EPMC7041723 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature