Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2.

ABSTRACT: Uric acid is a common metabolite found in mammals' serum. Recently, several metabolites have been identified that modulate aging, and uric acid levels are positively correlated with mammals' lifespan. However, the molecular mechanisms underlying this are largely undefined. Here we show that uric acid, an end product of purine metabolism, enhances the resistance of oxidative stress and extends the life span of Caenorhabditis elegans (C. elegans). We show that uric acid enhances a variety of pathways and leads to the upregulation of genes that are required for uric acid-mediated life span extension. We find that the transcription factors DAF-16/FOXO, SKN-1/NRF2 and HSF-1 contribute to the beneficial longevity conferred by uric acid. We also show that uric acid induced life span extens

SUBMITTER: Wan QL 

PROVIDER: S-EPMC7041755 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature