Identification of an immune-related risk signature for predicting prognosis in clear cell renal cell carcinoma.

ABSTRACT: Immune status affects the initiation and progression of clear cell renal cell carcinoma (ccRCC), the most common subtype of renal cell carcinoma. In this study, we identified an immune-related, five-gene signature that improves survival prediction in ccRCC. Patients were classified as high- and low-risk based on the signature risk score. Survival analysis showed differential prognosis, while principal component analysis revealed distinctly different immune phenotypes between the two risk groups. High-risk patients tended to have advanced stage, higher grade disease, and poorer prognoses. Functional enrichment analysis showed that the signature genes were mainly involved in the cytokine-cytokine receptor interaction pathway. Moreover, we found that tumors from high-risk patients had higher

SUBMITTER: Hua X 

PROVIDER: S-EPMC7041771 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature