HDQLIFE and neuro-QoL physical function measures: Responsiveness in persons with huntington's disease.

ABSTRACT:

Background

Huntington's disease (HD) is a neurological disorder that causes severe motor symptoms that adversely impact health-related quality of life. Patient-reported physical function outcome measures in HD have shown cross-sectional evidence of validity, but responsiveness has not yet been assessed.

Objectives

This study evaluates the responsiveness of the Huntington Disease Health-Related Quality of Life (HDQLIFE) and the Quality of Life in Neurological Disorders (Neuro-QoL) physical function measures in persons with HD.

Methods

A total of 347 participants completed baseline and at least 1 follow-up (12-month and 24-month) measure (HDQLIFE Chorea, HDQLIFE Swallowing Difficulties, HDQLIFE Speech Difficulties, Neuro-QoL Upper Extremity Function, and/or Neuro-QoL Lo

SUBMITTER: Carlozzi NE 

PROVIDER: S-EPMC7041888 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature